Infections Department

Overview

There are 73 beds in the Department of Infectious Diseases which is located in Binjiang Hospital's Emergency Building (Building 6). Dual-purpose wards for infectious diseases are located on the third and fourth floors. These wards may be quickly transformed into negative-pressure isolation rooms if necessary. They are intended for both routine and epidemic use. Seven negative-pressure rooms make up the specialized Tuberculosis Ward, which is located on the fifth level of the Infectious Diseases Building. Additionally, the facility has a separate tuberculosis laboratory and a dedicated negative-pressure operating room.

Supported by Zhejiang Genetic Diagnosis Center and Zhejiang Laboratory Testing Center, the department is the deputy leading unit of the Pediatric Infectious Diseases Group of Chinese Medical Association, and the leading unit of the Pediatric Infectious Diseases Group of Infectious Diseases Branch of Zhejiang Medical Association. The department is composed of experienced doctors and nurses, including 2 doctoral tutor, 5 chief physicians, 7 deputy chief physician, 13 attending physicians, and 7 resident physicians.

The department has long been dedicated to teaching in Chinese and English in the field of pediatric infectious diseases, and has achieved remarkable results in scientific research. It has undertaken multiple national and provincial-level research projects, including the National Natural Science Foundation of China and various provincial-level research topics. It has a high academic level in the molecular diagnosis of bacterial and viral infections in children, the pathogenesis of HCMV infection, EB virus infection, H1N1 influenza virus infection, tuberculosis infection, pediatric liver disease, cholangitis, lymphadenopathy of various etiologies, and herpes virus infection. The establishment of the 16SrRNA gene chip for the diagnosis of bacterial infection for the first time has attracted great attention from domestic and foreign counterparts, and has been cited by peers for many times. Furthermore, the department effectively developed and standardized the use of premenstrual subarachnoid puncture combined with intrathecal vancomycin injection for the targeted treatment of refractory/severe purulent meningitis. This closes a gap in Zhejiang province's pediatric application of this technology and opens up a new, effective therapeutic avenue for refractory intracranial infections. Also, it has written, drafted or participated in recommendations or guidelines for the diagnosis and treatment of pediatric infectious diseases.


Service

(1) Pediatric infectious diseases: fever of unknown origin, sepsis, bacterial meningitis, Epstein-Barr virus infection, cytomegalovirus infection, fever eruptive disease, intestinal infection, tuberculosis, cholangitis, enlarged lymph nodes, fungal and parasitic infection.

(2) Treat infectious diseases during outbreaks of infectious diseases: hand-foot-and-mouth disease, influenza A and B, COVID-19, tuberculosis, etc.


Professional Features

Early diagnosis and basic research of infectious diseases in children:

(1) Established a gene diagnosis technology for pediatric infectious diseases, mainly focusing on the development of gene chips for bacterial infection and herpes viruses.

(2) The human cytomegalovirus resistance gene and latent infection mechanism were studied with the help of molecular biology techniques such as RNA interference and antisense RNA.

(3) Used immunoblotting fluorescence microscopy and CRISPR-Cas9 gene editing technology to regulate the mechanism of DCs anti-influenza A virus on cell autophagy.

(4) Multi-center clinical study on drug resistance surveillance and epidemiological investigation of streptococcus pneumonia, MRSA and ESBL-producing negative bacilli, and haemophilus influenza.

(5) National multi-center clinical study of EB virus infection.

(6) Pathogen culture and drug sensitivity, specific antigens and antibodies, specific genes and other pathogenic examinations.

(7) Developed and standardized the use of premenstrual subarachnoid puncture combined with intrathecal vancomycin injection for the targeted treatment of refractory/severe purulent meningitis.



Research

With long-term dedication to teaching in both Chinese and English in the field of pediatric infectious diseases, the department has achieved remarkable accomplishments in scientific research. It has undertaken numerous national and provincial-level research projects, including those funded by the National Natural Science Foundation of China and various provincial-level initiatives. The faculty members have published a substantial number of academic papers, among which are multiple high-quality studies indexed in SCI.

It has a high academic level in the molecular diagnosis of bacterial and viral infections in children, the pathogenesis of HCMV, Epstein-Barr virus, H1N1 influenza virus, TORCH intrauterine infection, tuberculosis and herpes virus infection. The department established the 16SrRNA gene chip for the diagnosis of bacterial infections for the first time, developed a common herpes virus diagnostic chip, and added the content of 16SrRNA gene diagnosis in the revised plan for the diagnostic standard of neonatal sepsis in 2003. It has been cited many times by domestic and foreign magazines, covering most authoritative journals of international pediatrics, including Pediatrics, Pediatric Research, Journal of Pediatrics, etc. And the related diagnostic chips and technologies of it have obtained national patents and have independent intellectual property rights. Furthermore, the department effectively developed and standardized the use of premenstrual subarachnoid puncture combined with intrathecal vancomycin injection for the targeted treatment of refractory/severe purulent meningitis. This closes a gap in Zhejiang province's pediatric application of this technology and opens up a new, effective therapeutic avenue for refractory intracranial infections.


Expert Team

No. Name Academic Rank

1

Huang Lisu

Chief Physician

2

Chen Yinghu

Chief Physician

3

Hua Chunzhen

Chief Physician

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