Neurodevelopmental disorders (with a focus on autism spectrum disorder), and pediatric sleep disorders

My research focuses on the mechanisms and innovative treatments of autism spectrum disorder (ASD) and sleep-related brain disorders. Clinically, I lead a national, multicenter prospective ASD cohort study (ChiCTR2500101955), aimed at elucidating disease pathophysiology, refining biological subtyping, and identifying actionable intervention targets to advance precision medicine. In parallel, my basic neuroscience research bridges clinical observations with mechanistic insights. Using rodent and zebrafish models, I employ optogenetics, in vivo two-photon microscopy, and cell-type–specific calcium imaging to model genetic and neurobiological findings from our cohort and to functionally interrogate candidate pathways, thereby validating potential therapeutic targets.