Endocrinology Department was established in 1994. It is the key medical (innovation) discipline of Zhejiang Province, Chinese Children's Diabetes Management Branch Center of the World Diabetes Foundation (WDF), China Type 1 Diabetes Integrated Medical Management Model Demonstration Base and Zhejiang Children's Growth and Development Quality Control Center. Professor Fu Junfen, pace-setter in endocrinology, is the executive vice president of the hospital, secretary-general of the Asia-Pacific Pediatric Endocrinology Society, head of Endocrine Genetic Metabolism Group of Chinese Medical Association, and deputy chairman of Adolescent Medicine Professional Committee of Chinese Medical Doctor Association. It has an international professional team in the field of pediatric endocrinology, with 20 specialists, including 8 chief physicians, 3 deputy chief physicians, and 7 attending physicians; 2 doctoral supervisors and 2 master supervisors; two 151 talents in the new century of Zhejiang Province; 7 of them with doctoral degree, 15 with master degree, and 18 nursing staff (all with a bachelor's degree). Many team members have been trained in the United States, Germany, Japan, the United Kingdom and other international research institutions or children's hospitals. It has endocrinology specialist clinic, diabetes integrated management special clinic, disorder of sex development multidisciplinary team clinic, growth and development clinic, etc. The annual outpatients are about 73,000, and annual admitted inpatients are nearly 6,000 every year.
The department provides care for a large number of children with endocrine and genetic metabolic diseases such as short stature, precocious puberty, obesity, diabetes, thyroid disease, adrenal disease, disorder of sex development, diabetes insipidus, bone metabolism abnormalities, etc. In addition to routinely carrying out endocrine stimulation tests, it is also the first in China to carry out quantitative testing of child liver proton magnetic resonance hydrogen spectroscopy (1H MRS), MMTT islet function evaluation test, dual-energy X-ray whole body fat and bone density detection, obese breathing sleep monitoring, diabetes 3 “C” treatment and other special technologies.
Endocrinology Department attaches great importance to teaching and scientific research. It has long been responsible for the teaching of endocrine genetic metabolism and adolescent medicine in the eight-year, seven-year, and five-year programs, international students in School of Medicine of Zhejiang University and City College of Zhejiang University. It has made outstanding contributions to the basic research on children's short stature, obesity, non-alcoholic fatty liver disease, metabolic syndrome and insulin resistance mechanism. In recent years, the department has led 1 major chronic non-communicable disease prevention and control research in the national key research and development plan, and has won 12 national natural science funds, sub-projects of the "Eleventh Five-Year" and "Twelfth Five-Year" scientific and technological support plans, and key scientific research projects of international cooperation, more than 20 research projects of Zhejiang Science and Technology Department and Zhejiang Natural Science Foundation.
The department won a second prize of National Science and Technology Progress, a first prize and two second prizes of Zhejiang Provincial Science and Technology Progress, and a first prize and two second prizes and a third prize of Zhejiang Provincial Medicine and Health Innovation. A total of more than 200 papers have been published, including more than 100 SCI papers. And 11 books have been published (editor-in-chief twice, associate editor once and coeditor 8 times).
The department has created Healthy Growth Website —— www.jkwcz.com and WeChat public account to better serve patients, families and the society. The endocrinology team regularly conducts various endocrine health education lectures and parent schools for the public, related to obesity, diabetes, growth and development in various media such as Zhejiang TV Station, Zhejiang Famous Medical Center, Qianjiang Evening News, and City Express, etc.
(1) Pediatric endocrine diseases: precocious puberty, short stature, obesity and related complications, TURNER syndrome, hypogonadism, hypothyroidism, hyperthyroidism, type 1 diabetes, type 2 diabetes, hypoglycemia, diabetes insipidus, congenital adrenal hyperplasia, adrenal hypofunction, hyperaldosteronism, hyperparathyroidism, hypoparathyroidism, polypituitary hormone deficiency, hypokalemia, autoimmune polyglandular disease, etc;
(2) Other pediatric common and complicated diseases
(1) There are multiple sub-specialty clinics for child growth and development, diabetes management, obesity, PCOS, disorder of sex development, multi-disciplinary team consultation, thyroid disease, pituitary disease, abnormal calcium and phosphorus metabolism, genetic rare diseases, hypoglycemia, etc.
(2) Clinical inspection tests are routinely carried, such as growth hormone drug challenge test, gonadotropin-releasing hormone challenge test, glucose tolerance and insulin release test, ACTH challenge test, HCG challenge test, dexamethasone inhibition test, etc.
(3) It took the lead in carrying out quantitative testing of child liver proton magnetic resonance hydrogen spectroscopy (1H MRS), MMTT islet function evaluation test, dual-energy X-ray whole body fat and bone density detection, minimally invasive thyroid and liver puncture, obesity respiratory sleep monitoring, diabetes 3 "C" treatment and other special technologies.
It is the earliest unit in China to establish a child obesity monitoring system and carry out research on child and adolescent obesity and metabolic syndrome, and many diagnosis and treatment technologies of the department have reached the international advanced level, including obese children MMTT islet function assessment technology, liver hydrogen proton magnetic resonance spectroscopy (1H MRS) quantitative analysis technology, diabetes 3 "C" treatment technology, miR152 monitoring of children's non-alcoholic fatty liver disease progress technology and many other unique technologies. A series of clinical studies such as MetS Comprehensive Prevention and Treatment Technology for Children and Adolescents and Diabetes Prevalence and Nutrition and Influencing Factors were carried out to establish national multicenter queue of childhood obesity and metabolic syndrome and cohort of children with type 1 diabetes, with 3,000 and 900 people respectively, ranking first in the country. It is the first in China to propose a diagnostic standard that meets the metabolic syndrome of Chinese children. It has established a waist circumference percentile database and blood lipid distribution map for children and adolescents between 6 and 16 years old. It also innovatively proposed the ability of waist/height ratio to predict the abnormal risk of MetS and components, and the early warning effect of IMT and vWF on the damage of MetS arterial endothelium in children. The research results of these were published in JAMA pediatric (IF10.25), Int J of Obesity, Clinical Endocrinology, Pediatric Diabetes, Obesity and other related TOP journals.
The department took the lead in formulating four national guidelines for consensus, including Chinese Children and Adolescents' Metabolic Syndrome Definition and Prevention and Treatment Recommendations, Chinese Expert Consensus on the Diagnosis and Treatment of Type 2 Diabetes in Children and Adolescents, Expert Consensus on Single-Gene Diabetes and Clinical Diagnosis and Information for Children and Expert Consensus on the Diagnosis and Treatment of Nonalcoholic Fatty Liver Diseases in Children. It participated in the formulation of 4 international guidelines such as the International Children and Adolescent Diabetes ISPAD Diagnosis and Treatment Guidelines and the Global Child Nutrition Consensus. Two multi-center clinical studies have been cited by authoritative international guidelines for the prevention and treatment of childhood obesity and the international consensus on adolescent type 2 diabetes, which were published in the JCEM and Diabetes Care ——TOP journals in Endocrinology. Professor Fu Jufen was invited to write expert reviews of international magazines twice, and invited to give conference reports and special lectures at important international conferences many times. Every year, many internationally renowned endocrinologists from the United States, Germany, the United Kingdom, Japan, New Zealand, and Singapore are invited to participate in the “Qianjiang Pediatric Adolescent Medicine Summit Forum” organized by the hospital. At the same time, it has established mutual visits and in-depth cooperation with many medical and scientific research institutions such as Boston Children's Hospital of Harvard Medical School, Children's Hospital of Philadelphia, Duke University, Auckland University of New Zealand, and Canadian Academician Team. In 2017, a strategic cooperation agreement on chronic non-communicable diseases at the national level was signed with New Zealand.
In recent years, it has led 1 major chronic non-communicable disease prevention and control research in the national key research and development program, and has won more than 20 research projects, including 12 national natural funds, “11th Five-Year” and “12th Five-Year” scientific and technological support plan sub-projects, international cooperation key scientific, major projects of Department of Science and Technology of Zhejiang Province, Zhejiang Natural Science Foundation, etc. It won 1 National Science and Technology Progress Second Prize (7/12), 1 First Prize, 2 Second Prizes of Zhejiang Provincial Science and Technology Progress and 1 First Prize, 2 Second Prizes and 1 Third Prize of Zhejiang Provincial Medicine and Health Innovation. A total of more than 200 papers have been published by staff in the department, including more than 100 SCI papers. And 11 books have been published (editor-in-chief twice, associate editor once and coedit 8 times).