Scientific research is a very important part of hospital mission as a teaching hospital affiliated to Zhejiang University. The hospital plays an active role in various areas of scientific research. The Pediatric Research Institute of Zhejiang University is located at the hospital. The hospital strives to work on cutting-edge research and technology to improve clinical care and treatments. Dozens of active national and provincial scientific research programs are carried on every year. Many of research projects have received award from Natural Science Foundation of China and other organizations over the past years. Many research articles, expert guidelines, consensus, and monographs were published by hospital faculty.

Through the hard work made by several generations of health care providers at the Children's Hospital, remarkable results have been achieved. Two national centers were accredited—National Clinical Research Center for Child Health and National Children's Regional Medical Center. Pediatrics was approved as national key discipline. Neonatology, gastroenterology, respiratory medicine, and intensive care medicine were approved as national key clinical discipline. Two key laboratories –Key Laboratory of Reproductive Genetics and Key Laboratory of Diagnosis and Treatment of Neonatal Disease of Zhejiang Province, three innovation teams—Zhejiang Provincial Key Innovation Team for Early Screening and Intervention for Child Birth Defects, Clinical Medicine Innovation Team of Zhejiang University School of Medicine led by Prof. Shu Qiang and Prof. Fu Junfen were established. Six provincial platforms, three international platforms, and 13 national platforms were built up. Neonatology, cardiothoracic surgery, child healthcare, pediatric perioperative medicine, adolescent medicine, nephrology, cardiovascular, anesthesiology, hematology/oncology were approved as Zhejiang provincial key disciplines.